Dr. Bonnie Deroo
- In many species, estrogens act on their target cells by binding to and activating the estrogen receptor (ER), a transcription factor that regulates the expression of estrogen-responsive genes. Our goal is to understand how estrogen is involved in human fertility and cancer.
Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A, Chiariotti L, Malorni A, Abbondanza C, Avvedimento EV. (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
Science 319: 202-6 Read more»
Le Romancer M, Treilleux I, Leconte N, Robin-Lespinasse Y, Sentis S, Bouchekioua-Bouzaghou K, Goddard S, Gobert-Gosse S, Corbo L. (2008) Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
Mol Cell. 31:212-21. Read more»
We use mice lacking Estrogen Receptor beta for many of our studies. These mice have fewer litters than normal mice and ovulate less frequently. They provide a model to study why estrogen is critical for fertility. We also have projects not involving mice (see Research).